MECHANISM OF ACTION OF RESERPINE AND INSULIN ON GASTRIC AMINES AND GASTRIC ACID SECRETION, AND THE EFFECT OF MONOAMINE OXIDASE INHIBITION

¹ Department of Pharmacology, The University of Texas Southwestern Medical School, Dallas, Texas

Reserpine and insulin provoke gastric acid secretion and produce gastric lesions in the rat. Both agents lower stomach histamine content while reserpine also lowers serotonin content. Gastric acid secretion, lesions, and histamine lowering produced by either agent are greatly inhibited or blocked by vagotomy. A small part of reserpine-induced effects is mediated by ganglionic stimulation. The monoamine oxidase inhibitor, PIH, inhibits reserpine-induced gastric acid secretion, serotonin lowering, and lesion formation but does not alter the histamine-lowering action of reserpine. PIH has no effect on insulin-induced lesions, acid secretion, or histamine lowering. It is concluded that both reserpine and insulin cause gastric histamine release by central vagal stimulation, leading, in turn, to gastric acid secretion. It is further concluded that PIH protects against reserpine-induced responses by a local action, possibly due to the presence of a high free serotonin concentration.

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