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Journal of Pharmacology And Experimental Therapeutics, Vol. 141, Issue 3, 274-279, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

METABOLIC EFFECTS OF THEOPHYLLINE IN CARDIAC AND SKELETAL MUSCLE

Marilyn E. Hess 1, Daniel Hottenstein 1, Joseph Shanfeld 1, and Niels Haugaard 1

1 Department of Pharmacology, Schools of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Theophylline potentiates the stimulatory effects of epinephrine on phosphorylase a activity in rat diaphragm.

Epinephrine or theophylline causes an increase in the activity of cardiac phosphorylase a; the latter drug does not require endogenous catecholamines to exert its effect.

Combined administration of theophylline and epinephrine in the perfused heart produces a greater increase in phosphorylase activity than the sum of the effects of each drug.

The stimulation of phosphorylase by theophylline in the perfused heart from reserpine-treated animals was greater than that observed with hearts from untreated animals. Phosphorylase a activity was increased in hearts from rats given reserpine prior to sacrifice.

Submitted on April 10, 1963
Accepted on May 23, 1963






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