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Journal of Pharmacology And Experimental Therapeutics, Vol. 141, Issue 2, 185-194, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

RELEASE OF AUTONOMIC MEDIATORS IN CARDIAC TISSUE BY DIRECT SUBTHRESHOLD ELECTRICAL STIMULATION

Frank F. Vincenzi 1 and Theodore C. West 1

1 Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington

Electrical stimuli which are subthreshold for myocardial excitation have been shown to be effective in causing the release of autonomic mediators in several types of cardiac tissue derived from rabbit, guinea pig, dog, and cat.

Strength-duration data have been presented illustrating the relative case with which subthreshold release of the autonomic mediators may be demonstrated in rabbit SA node, AV node, and left atrium.

It is proposed that both subthreshold and threshold electrical stimulation act upon intramyocardial autonomic nervous elements to cause the release of acetylcholine and norepinephrine.

The significance of the release of acetylchohine and/or norepinephrine in procedures involving electrical stimulation is discussed.

Submitted on March 11, 1963
Accepted on May 10, 1963




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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.