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Journal of Pharmacology And Experimental Therapeutics, Vol. 141, Issue 2, 180-184, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

SYMPATHOMIMETIC ACTIONS OF CIS-2-AMINO-4-METHYL-5-PHENYL-2-OXAZOLINE

J. Yelnosky 1 and R. Katz 1

1 Biological Research Department, McNeil Laboratories, Inc., Fort Washington, Pennsylvania

The results of this study indicate that McN-822 belongs to a class of sympathomimetic agents that produce effects in normal dogs and have little or no effect in dogs presumably depleted of catecholamines by reserpine. This suggests McN-822 produces its sympathomimetic effects indirectly through the release of catecholamines. The marked sympathomimetic effects resulting from injections of reserpine and McN-822 in normal dogs are believed to be due to an enhanced release of catecholamines under the combined influence of both compounds.

Submitted on March 18, 1963
Accepted on April 26, 1963




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