A COMPARATIVE PHARMACOLOGICAL STUDY OF SYNTHETIC ELEDOISIN AND SYNTHETIC BRADYKININ

¹ Pharmacological Laboratories, Sandoz Ltd., Basle, Switzerland

The synthetically produced and analytically pure endecapeptide eledoisin (E) anti nonapeptide bradykinin (B) were compared in 20 experimental procedures. Qualitatively similar, although quanutitatively often different effects were found in vitro on the guinea-pig and rabbit ileum, rat and rabbit uterus, rabbit mammary gland as well as in serum inactivation experiments and in situ on the guinea-pig bronchial muscle, the cat and rat uterus, the blood pressure of dogs, cats, rabbits and rats, the capillary permeability of guinea pigs and rats and the rabbit mammary gland. Qualitatively different effects were observed in vitro on the rat duodenum, the hen rectal caecum and in situ on the chicken blood pressure. These findings as well as the difference in the influence of acetylsalicylic acid on the bronchial effect of E and B suggest that although E can be regarded as a member of the kinin family, it is a rather peculiar representative of this class of substances and may well act on receptors other than those involved in the action of B. The metabolism of E and B seems also to be somewhat different.