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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 3, 287-294, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

LIPOLYSIS IN ADIPOSE TISSUE: EFFECTS OF dl-3,4-DICHLOROISOPROTERENOL AND RELATED COMPOUNDS

William C. Love 1, Lucinda Carr 1, and James Ashmore 1

1 Department of Pharmacology, Indiana University Medical School, Indianapolis, Indiana

Increased free fatty acid production by rat epididymal adipose tissue exposed to catecholamines ACTH, TSH and glucagon in vitro was inhibited by dl-3,4-dichloroisoproterenol at concentrations greater than 10-4 molar. This phenomenon was independent of glucose and apparently involved inhibition of the activation of lipolysis rather than an increase in re-esterification of free fatty acid. Free fatty acid release by adipose tissue in vitro was increased by the lower concentrations of dl-3,4-dichloroisoproterenol and maximum free fatty acid production was achieved at 10-5 molar.

dl - 1 - (2,4 - Dichlorophenyl) - 2 - t -butyl-aminoethanol was similar in action to dl-3,4-dichloroisoproterenol in that at concentrations above 10-4 molar it effectively inhibited free fatty acid release due to catecholamines; however, unlike dl-3,4-dichloroisoproterenol and several other compounds it did not stimulate free fatty acid production in vitro at any concentration studied.

Submitted on October 14, 1962
Accepted on March 4, 1963






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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.