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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 3, 269-277, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

FORMATION OF METABOLITES FROM NICOTINE BY A RABBIT LIVER PREPARATION

N. M. Papadopoulos 1 and J. A. Kintzios 1

1 The Department of Pharmacology, Medical College of Virginia, Richmond, Virginia

The metabolism of nicotine was studied using a rabbit liver supernatant preparation with TPNH. Two-directional chromatography and radioautography revealed 8 major nicotine metabolites. Four of these had the satire mobilities as nornicotine, demethylcotinine and pyridylacetic acid standards. The other four have not been identified. Nornicotine, cotinine and demethylcotinine have been isolated and identified by physical and chemical methods. The oxidative and demethylation processes in the metabolism of nicotine are discussed.

Submitted on December 13, 1962
Accepted on March 13, 1963




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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.