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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 2, 229-235, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE PRESENCE AND DISTRIBUTION OF TYRAMINE IN MAMMALIAN TISSUES

Sydney Spector 1, Kenneth Melmon 1, Walter Lovenberg 1, and Albert Sjoerdsma 1

1 Experimental Therapeutics Branch, National Heart Institute, Bethesda, Maryland

By a combination of solvent extraction and fluorimetric assay, significant concentrations of tyramine have been measured in mammalian tissues. Criteria for identification of the material measured as tyramine were: (a) fluorescence properties; (b) behavior on paper and gas-liquid chromatography and (c) enzymatic conversion to p-hydroxyphenylacetic acid. The amine is present in amounts of 1 to 6 µg/g in various parts of the central nervous system of rat, rabbit, dog and cat. The highest concentrations were in the brain stem and spinal cord.

Submitted on December 28, 1962
Accepted on February 8, 1963






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