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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 2, 224-228, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF DOPAMINE beta-OXIDASE IN VIVO BY BENZYLOXYAMINE AND BENZYLHYDRAZINE ANALOGS

Branislav Nikodijevic 1, Cyrus R. Creveling 1, and Sidney Udenfriend 1

1 Laboratory of Clinical Biochemistry, National Heart Institute, Bethesda, Maryland

Procedures have been developed for evaluating effects of dopamine beta-oxidase inhibitors in vivo. Benzyloxyamine and some ring substituted analogues were found to be effective in vivo inhibitors in these test systems. However, only one of these agents produced even measurable effects on endogenous norepinephrine levels in guinea-pig tissues.

Submitted on January 5, 1963
Accepted on February 15, 1963






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