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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 2, 179-182, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF MONOAMINE OXIDASE INHIBITORS ON NEUROMYAL TRANSMISSION

Edmund G. Anderson 1 and Arthur Ammann 1

1 Department of Pharmacology, Seton Hall College of Medicine and Dentistry, Jersey City, New Jersey

The monoamine oxidase inhibitors, tranylcypromine, phenylisopropylhydrazmne, MO 911, ethyltryptamine, harmaline, amphetamine and methamphetamine all produced a reversible block of neuromyal transmission in the isolated rat phrenic nerve-diaphragm preparation. They did not block when application was restricted to the nerve and they increased the force of contraction of directly stimulated muscle. They did block the action of acetylcholine on the denervated diaphragm. It is concluded that these compounds block transmission by a mechanism not involving inhibition of monoamine oxidase.

Submitted on November 16, 1962
Accepted on February 7, 1963






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