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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 1, 60-66, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

ANALYSIS OF THE CARDIOVASCULAR EFFECTS OF DOPAMINE IN THE DOG

Robert H. McDonald Jr. 1 and Leon I. Goldberg 1

1 Department of Pharmacology and Department of Medicine (Section of Clinical Pharmacology), Emory University, Atlanta, Georgia

The cardiovascular effects of dopamine were studied in the anesthetized dog. Small doses (2 to 4 µg/kg) of the amine had little or no cardiac effect and produced a slight pressor-depressor effect. With intermediate doses (8 to 16 µg/kg), increments in heart contractile force and heart rate occurred and the effects on blood pressure were more pronounced. At the highest doses studied (32 to 64 µg/kg), marked increments in heart contractile force, heart rate and arterial pressure were observed. Analysis of the depressor phase of dopamine action indicated that this hypotensive effect was not blocked by dichloroisoproterenol, Dibenzyline, atropine, hexamethonium, or antihistamines. Studies of the effects of dopamine in preparations with constantly perfused limbs suggested that the depressor action of dopamine is the result of a reflex or a central nervous system effect.

Submitted on November 21, 1962
Accepted on January 2, 1963




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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.