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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 1, 41-45, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF PHENOLIC SUBSTANCES ON MOTOR NERVE ENDINGS

M. Otsuka 1 and Y. Nonomura 1

1 Department of Pharmacology, University of Tokyo, Japan

The mechanism of action of phenolic substances (phenol, catechol and hydroquinone) at the neuromuscular junction was studied. Use was made of intracellular recording of membrane potential and of ionophoretic micro-application of acetylcholine.

Phenolic substances greatly increased the size of end-plate potential in curarized nerve-muscle preparation without altering the sensitivity of the end-plate to acetylcholine. Phenols increased the degree of neuromuscular depression.

It is concluded that phenolic substances act on motor nerve endings increasing the amount of the transmitter released by a single nerve impulse.

Submitted on September 26, 1962
Accepted on December 26, 1962






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