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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 1, 111-116, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF RESERPINE AND SOME RELATED COMPOUNDS UPON THE LEVELS OF ADENINE NUCLEOTIDES, CREATINE PHOSPHATE AND INORGANIC PHOSPHATE IN THE RAT BRAIN IN VIVO

C. L. Kaul 1 and J. J. Lewis 1

1 Experimental Pharmacology Division, Institute of Physiology, The University, Glasgow, W.2, Scotland

The effects of some reserpine-like compounds on the adenine nucleotides, creatine phosphate and inorganic phosphate levels of the rat brain frozen in situ have been studied. The nonsedative compounds methoserpidine, reserpic acid and methyl reserpate were not active, but reserpine, syrosingopine and tetrabenazine decreased the ATP/ADP ratio—an effect due to a fall in ATP and an increase in ADP values. Although deserpidine caused reserpine-like sedation, it did not produce a statistically significant fall in ATP. Some correlation between the changes in ATP levels and the time course of reserpine-sedation was found in rats.

Submitted on October 15, 1962
Accepted on January 17, 1963






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