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Journal of Pharmacology And Experimental Therapeutics, Vol. 140, Issue 1, 103-110, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF UNILATERAL AND BILATERAL MEDIAL FOREBRAIN BUNDLE LFSIONS ON BRAIN SEROTONIN

John A. Harvey 1, Alfred Heller 1, and Robert Y. Moore 1

1 Departments of Psychology, Pharmacology and Anatomy, The University of Chicago, Chicago, Illinois

Rats with either unilateral or bilateral medial forebrain bundle lesions demonstrated a significant fall in brain serotonin levels. The effect of a unilateral lesion on total brain serotonin level was approximately half of that produced by a bilateral lesion. When the brains of unilateral lesioned rats were sectioned longitudinally into two hemi-brains and assayed separately, it was found that the fall in brain serotonin was entirely restricted to the hemi-brain containing the lesion. No fall in serotonin could be observed in the hemi-brain contralateral to the lesion. The percentage decrease of brain serotonin in the lesioned hemi-brain of rats with unilateral lesions was therefore the same as that seen with bilateral lesions.

Using bilateral lesioned rats it was found that serotonin began to fall between the second and third day after operation, and reached its maximum fall by the 12th postoperative day. The rate of serotonin fall between the second and 12th postoperative day was linear when log µg/g serotonin was plotted versus log time in days. This hyperbolic function was found to be Y = 0.594 (T-1)-.155 2 le T le 12 where Y is the concentration of serotonin in µg/g and T is the time in days.

The results of these experiments were interpreted as indicating the existence of serotonin- producing fibers within the medial forebrain bundle.

Submitted on October 26, 1962
Accepted on December 26, 1962




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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.