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Journal of Pharmacology And Experimental Therapeutics, Vol. 139, Issue 3, 337-344, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF TRYPTAMINE UPON THE ELECTRICAL ACTIVITY OF SINGLE HIPPOCAMPAL NEURONS

L. de Baran 1, G. Gogolak 1, V. G. Longo 1, and Ch. Stumpf 1

1 Department of Pharmacology, University of Vienna, Austria, and Istituto Superiore di Sanità, Rome, Italy

The effect of tryptamine on the electrical activity of single hippocampal cells in curarized rabbits has been recorded by means of micro-electrodes. Unit activity was registered from pyramidal, granule and subicular cells.

Tryptamine in doses of 5 to 25 mg/kg consistently inhibited the firing of the pyramidal and subicular units while producing an augmentation of the firing rate of two out of three granule cells.

The present findings are discussed in relation to the behavioral and electroencephalographic effects of tryptamine and related compounds.

Submitted on July 12, 1962
Accepted on December 3, 1962






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