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Journal of Pharmacology And Experimental Therapeutics, Vol. 139, Issue 3, 296-303, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

INFLUENCE OF SEVERAL ADRENERGIC DRUGS ON SYNAPTIC TRANSMISSION THROUGH THE SUPERIOR CERVICAL AND THE CILIARY GANGLIA OF THE CAT

Efraín G. Pardo 1, Jorge Cato 1, Enrique Gijón 1, and Francisco Alonso-deFlorida 1

1 Departments of Physiology and Pharmacology, Universidad Nacional Antónoma de México, Mexico, D. F.

A study was made of transmission at the superior cervical ganglion and at the ciliary ganglion during the infusion of several adrenergic drugs. In what refers to blockade of transmission, epinephrine was more potent than norepinephrine, both were more potent than isoproterenol, and all of the catecholamines were more potent than amphetamine, ephedrine, phenylephrine or isometheptene. Very low rates of infusion of the catecholamines frequently produced enhancement of transmission which could be demonstrated most easily with isoproterenol. No significant differences were found between the sensitivity of the superior cervical ganglion and of the ciliary ganglion to either blockade or facilitation by these compounds.

Submitted on October 22, 1962
Accepted on December 5, 1962






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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.