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Journal of Pharmacology And Experimental Therapeutics, Vol. 139, Issue 1, 60-68, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

INHIBITORY EFFECT OF ACETYLCHOLINE ON GLYCOGENOLYSIS IN THE ISOLATED GUINEA-PIG HEART

Norma H. Vincent 1 and Sydney Ellis 1

1 Department of Pharmacology, Woman's Medical College, Philadelphia, Pennsylvania

In perfused guinea-pig hearts acetylcholine antagonized completely the glycogenolytic effect of epinephrine. By electrically controlling the ventricular rate, the inhibitory effect of acetylcholine upon epinephrine-induced glycogenolysis was shown to be independent of the negative chronotropic action of acetylcholine.

Acetylcholine alone did not elevate significantly cardiac glycogen.

Dichloroisoproterenol inhibited the glycogenolytic, chronotropic, and inotropic effects of epinephrine; veratramine prevented a rise above control cardiac rate without inhibiting the glycogenolytic effect of epinephrine.

Theophylline-induced glycogenolysis was completely antagonized by acetylcholine.

Anoxic glycogenolysis in the atria was significantly inhibited by acetylcholine; anoxic glycogenolysis in the ventricle was slightly, but not significantly inhibited.

The possible mechanism of this inhibitory effect of acetylcholine upon glycogenolysis is discussed in the light of recent publications.

Submitted on August 21, 1962
Accepted on September 17, 1962






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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.