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Journal of Pharmacology And Experimental Therapeutics, Vol. 139, Issue 1, 110-113, 1963
Copyright © 1963 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF CORTISOL ON THE ELECTROSHOCK SEIZURE THRESHOLDS IN DEVELOPING RATS

Antonia Vernadakis 1 and Dixon M. Woodbury 1

1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

The electroshock thresholds required to elicit the various patterns of sequentially developing seizures were determined in control and cortisol-treated rats during postnatal maturation.

In control animals the threshold for eliciting forelimb flexion decreased between the 13th and 15th days; the threshold for forelimb extension associated with hindlimb flexion decreased between the 16th and the 17th day; the threshold for hindlimb extension decreased up to about 4 weeks of age and slowly increased thereafter.

When cortisol was administered to rats for a 4-day period during the age of 8 to 15 days, the electroshock thresholds for all four seizure patterns were lowered as compared to those of the controls. However, cortisol administered to rats during the age period between 4 and 7 days after birth either elevated or did not affect the electroshock thresholds for any of the four seizure patterns.

The age-dependent biphasic effect of cortisol on brain excitability is thought to be related to its influence on myelination of the higher nervous centers.

Submitted on June 29, 1962
Accepted on October 22, 1962






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Copyright © 1963 by the American Society for Pharmacology and Experimental Therapeutics.