JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kopin, I. J.
Right arrow Articles by Gordon, E. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kopin, I. J.
Right arrow Articles by Gordon, E. K.
Journal of Pharmacology And Experimental Therapeutics, Vol. 138, Issue 3, 351-359, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM OF NOREPINEPHRINE-H3 RELEASED BY TYRAMINE AND RESERPINE

Irwin J. Kopin 1 and Edna K. Gordon 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, U. S. Department of Health, Education and Welfare, Public Health Service, Bethesda, Maryland

The fate of norepinephrine-H3 released from binding sites by the action of reserpine and tyramine has been examined. As a result of tyramine administration the bound catecholamines are released directly into the circulation; a small portion is metabolized in the tissue prior to release, and this, predominantly by O-methylation. Reserpine, on the other hand, depletes tissue of the catecholamine by metabolism within the tissue, predominantly by deamination; little norepinephrine is released into an active form. These results are discussed in relation to the metabolic fate of the bound pools of norepinephrine.

Submitted on August 20, 1962




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
S. A. Marchitti, R. A. Deitrich, and V. Vasiliou
Neurotoxicity and Metabolism of the Catecholamine-Derived 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde: The Role of Aldehyde Dehydrogenase
Pharmacol. Rev., June 1, 2007; 59(2): 125 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
G. Eisenhofer, I. J. Kopin, and D. S. Goldstein
Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine
Pharmacol. Rev., September 1, 2004; 56(3): 331 - 349.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. J. Schildkraut, P. R. Draskoczy, and P. S. Lo
Norepinephrine Pools in Rat Brain: Differences in Turnover Rates and Pathways of Metabolism
Science, May 7, 1971; 172(3983): 587 - 589.
[Abstract] [PDF]

Home page
 ScienceHome page
A. J. Mandell and C. E. Spooner
Psychochemical Research Studies in Man
Science, December 27, 1968; 162(3861): 1442 - 1453.
[PDF]

Home page
 ScienceHome page
J. J. Schildkraut and S. S. Kety
Biogenic Amines and Emotion
Science, April 7, 1967; 156(3771): 21 - 30.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.