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Journal of Pharmacology And Experimental Therapeutics, Vol. 138, Issue 3, 343-346, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

DIFFERENTIATION BETWEEN THE DIURETIC EFFECT OF PYROGEN (PIROMEN) AND A PREPARATION OBTAINED FROM HUMAN URINE

J. Maxwell Little 1 and Emily A. Angell 1

1 Department of Physiology and Pharmacology, The Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, North Carolina

The diuretic effect of pyrogen in the dog, reported by Brandt et al. (1956), has been confirmed. Incubation in the boiling water bath at pH 3 of dilute solutions of the urinary diuretic factor and of pyrogen (Piromen) showed a diminished diuretic activity for the urinary factor with inactivation in 2 of 6 preparations, while there was inactivation in 4 of 5 lots of pyrogen. Incubation of both types of preparations in the boiling water bath at pH 10 inactivated the urinary diuretic factor, while the activity of pyrogen was essentially unaffected by this treatment.

The diuretic activity of the preparations from human urine cannot be ascribed to a contamination with pyrogen, and therefore the preparations from urine have a specific diuretic effect on the unanesthetized dog.

Submitted on August 22, 1962






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.