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Journal of Pharmacology And Experimental Therapeutics, Vol. 138, Issue 3, 337-342, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF BRIEF RESTRAINT ON THE CONVULSIVE THRESHOLD OF MICE

Ewart A. Swinyard 1, N. Radhakrishnan 1, and Louis S. Goodman 1

1 Departments of Pharmacology, University of Utah College of Pharmacy and College of Medicine, Salt Lake City, Utah

The effect of brief periods of body restraint on the a.c. electroshock seizure threshold, low-frequency electroshock seizure threshold, and intravenous pentylenetetrazol seizure threshold was investigated in mice. Restraint significantly lowered threshold as measured by all three technics; maximum effect was observed almost immediately after restraint. Adaptation to the effect of restraint occurred rapidly. In adrenalectomized mice, restraint had no such lowering effect on the seizure threshold. In view of the fact that a small dose of intravenously injected epinephrine increased the susceptibility of mice to experimentally induced seizures and that brief periods of restraint rapidly induced hyperglycemia, it is suggested that the observed increase in brain excitability caused by restraint is the result of the effect of endogenously released epinephrine on the central nervous system.

Submitted on July 6, 1962




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.