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Journal of Pharmacology And Experimental Therapeutics, Vol. 138, Issue 3, 322-328, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF 2-PAM AND SUCCINYLCHOLINE ON NEUROMUSCULAR TRANSMISSION IN THE FROG

Charles Edwards 1 and Kazuo Ikeda 1

1 Department of Physiology, University of Minnesota, Minneapolis, Minnesota

In the Mg-blocked frog nerve-muscle preparation, the end-plate potential is increased by 2-PAM, and decreased by succinylcholine (SCh). Acetylcholine release was determined statistically as the average number of quanta released by each nerve impulse, 2-PAM increased the number of quanta released while SCh apparently reduced the number although it may have affected invasion of the nerve terminals. The agents had little or no effect on the sensitivity of the post-junctional membrane to ACh. It is concluded that the agents act presynaptically.

Submitted on August 7, 1962






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.