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Journal of Pharmacology And Experimental Therapeutics, Vol. 138, Issue 2, 194-199, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

ON THE MECHANISM OF THE NOREPINEPHRINE RELEASE PRODUCED BY agr-METHYL-META-TYROSINE

Sidney Udenfriend 1 and Perola Zaltzman-Nirenberg 1

1 Laboratory of Clinical Biochemistry, National Heart Institute, National Institutes of Health, Bethesda, Maryland

It has been shown that agr-methyl-meta-tyrosine (agr-MMT) must be decarboxylated in order to bring about release of norepinephrine from tissues. agr-Methyl-meta-tyramine and aramine, metabolic products of agr-MMT, are even more potent with respect to norepinephrine releasing activity. Thus agr-MMT, and no doubt agr-methyl-dopa, represent unique ways of administering the corresponding pharmacologically active amines. Far less than stoichiometric amounts of the agr-methyl-meta-tyramines are required to bring about and maintain depletion of norepinephrine.

Submitted on July 24, 1962




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.