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Journal of Pharmacology And Experimental Therapeutics, Vol. 138, Issue 2, 145-153, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF 5-HYDROXYTRYPTAMINE ON THE ANAEROBIC METABOLISM AND PHOSPHORYLASE ACTIVITY OF LAMELLIBRANCH GILL

K. E. Moore 1 and R. E. Gosselin 1

1 Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire

The effects of 5-HT and certain other cilioactive agents were studied on the anaerobic metabolism of excised gills of Modiolus demissus. In these gills endogenous glycogen serves as a substrate and lactic acid is a product of anaerobic glycolysis. The rate of anaerobic glycolysis but not of glucose uptake is markedly stimulated by low concentrations of 5-HT. At relatively high concentrations 5-HTP and epinephrine stimulate while acetylcholine inhibits the rate of anaerobic lactic acid production. BOL blocks but LSD mimics the 5-HT effects. The actions of 5-HT on the carbohydrate metabolism of these gills cannot be ascribed to an activation of gill phosphorylase.

Submitted on July 6, 1962






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.