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Journal of Pharmacology And Experimental Therapeutics, Vol. 138, Issue 1, 126-130, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

CYSTIC TUBULAR NEPHROPATHY AND DECREASE IN TESTICULAR WEIGHT IN RATS FOLLOWING ORAL METHOXYCHLOR TREATMENT

William W. Tullner 1 and John H. Edgcomb 1

1 Endocrinology Branch and Pathologic Anatomy Branch, National Cancer Institute, Bethesda, Maryland

In paired-feeding experiments in which 1% methoxychlor was added to the diet of weanling male rats there was marked reduction in the weights of the testes, seminal vesicles and ventral prostate. These effects on the male rat could be mediated through the estrogenic action of this compound inhibiting the production of anterior pituitary gonadotropins with consequent deficiencies in development of the male reproductive system.

Cystic tubular nephropathy was regularly observed in rats fed a 1% methoxychlor diet for 23 to 55 days. This nephropathy appears to he related to granular degeneration of the tubular epithelium and the formation of granular and cellular casts in the loops of Henle and distal convoluted tubules.

Submitted on July 2, 1962




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.