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Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 3, 361-364, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

SOME DETERMINANTS OF AMPHETAMINE TOXICITY IN AGGREGATED MICE

Gregory B. Fink 1 and Robert E. Larson 1

1 College of Pharmacy, Washington State University, Pullman, Washington

The toxicity of ansphetamine sulfate in aggregated mice was found to increase with greater body weight, but remained relatively constant as the dose of amphetamine was increased from 15 to 60 mg/kg. An increase in the number of mice from 5 to 10 per cage (degree of aggregation) greatly increased the toxicity of amphetamine. Within a temperature range of 20° to 27.5°C each 2.5°C rise in temperature produced a significant increase in amphetamine toxicity. A significant interaction occurred between degree of aggregation and temperature. The size of the cage in which the mice were confined (degree of confinement) had little influence on the toxicity of amphetamine in mice grouped 10 per cage. A decrease in cage size augmented amphetamine toxicity in mice grouped 5 per cage.

Submitted on June 11, 1962




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.