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Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 3, 329-333, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF AN INHIBITOR OF THE CHOLINESTERASE SYSTEM OF BRAIN AND CEREBROSPINAL FLUID

Malcolm B. Bowers Jr. 1 and George W. Ketner 1

1 Directorate of Medical Research, U. S. Army Chemical Research and Development Laboratories, Army Chemical Center, Maryland

Administration of sam produces cholinesterase inhibition and acetylcholine accumulation in dog and rabbit brain and cerebrospinal fluid. The quantitative relationships between the two compartments vary with the conditions of sarin administration and can be affected by treatment with oxime.

Submitted on April 23, 1962




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M. B. Bowers Jr., E. L. Hartmann, and D. X. Freedman
Sleep Deprivation and Brain Acetylcholine
Science, September 16, 1966; 153(3742): 1416 - 1417.
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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.