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Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 3, 319-323, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF HYDROCHLOROTHIAZIDE ON RENAL ELECTROLYTE GRADIENT IN GLUCOSE DIURESIS AND EXPERIMENTAL DIABETES INSIPIDUS

J. E. Baer 1, A. V. Brooks 1, R. M. Noll 1, and Karl H. Beyer 1

1 Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania

Hydrochlorothiazide (100 mg/kg, i.v.) did not affect the renal electrolyte gradient in uninfused dogs.

The renal electrolyte gradient was obliterated by infusion of 5% glucose alone (10 ml/min). Renal medullary sodium fell from 225 to 68 mEq/liter. The gradient was not re-established upon concurrent administration of hydrochlorothiazide.

An essentially normal renal sodium gradient was present in rats with experimental diabetes insipidus. Polyuria and polydipsia were suppressed by chlorothiazide or hydrochlorothiazide with no change in the renal sodium content.

Submitted on May 9, 1962




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.