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Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 2, 263-266, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

EVALUATION OF BORON COMPOUNDS FOR USE IN NEUTRON CAPTURE THERAPY OF BRAIN TUMORS. II. STUDIES IN MAN

W. H. Sweet 1, A. H. Soloway 1, and R. L. Wright 1

1 Neurosurgical Service, Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts

Three boron compounds which have been considered for use in the treatment of glioma patients, by neutron capture irradiation, have been evaluated in terminal individuals. They are 3-amino-4-carboxybenzeneboronic acid, m-boronosuccinanilic acid, and sodium perhydrodecaborate. The latter compound has been shown to be the most promising from the standpoint of low toxicity and has, in fact, been isolated unchanged, from the urine. Low toxicity is seen to be correlated with biological inertness and high chemical stability.

Submitted on April 20, 1962




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.