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Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 2, 213-218, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

SOME CHARACTERISTICS OF THE ISOLATED SYMPATHETIC NERVE-PULMONARY ARTERY PREPARATION OF THE RABBIT

John A. Bevan 1

1 Department of Pharmacology, UCLA Medical Center, Los Angeles, California

An isolated preparation of the distal 5 mm of the pulmonary artery of the rabbit and its sympathetic nerve supply has been developed. It responds to indirect (nerve) and direct electrical stimulation. The indirect, but not the direct, response is potentiated by cocaine and pretreatment with l-norepinephrine, and blocked by reserpine and yohimbine. Hexamethonium and atropine are without effect on the ratio of indirect to direct responses. The efferent nerve supply is probably postganglionic sympathetic in nature.

Submitted on March 14, 1962






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