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Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 2, 193-197, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

ACETYLCHOLINE-ATROPINE ANTAGONISM ON THE REFRACTORY PERIOD OF THE DOG ATRIUM IN SITU

Mary Lou Torchiana 1 and Evangelos T. Angelakos 1

1 Department of Physiology, Boston University School of Medicine, Boston, Massachusetts

The quantitative nature of the acetylcholine induced decrease in the absolute refractory period of the electrically driven dog atrium in situ has been demonstrated. Atropine antagonized the acetylcholine induced changes and the atropine

antagonism was "reversed" by increasing the acetylcholine concentration. The acetylcholine-atropine antagonism can be described as "surmountable" according to the classification proposed by Gaddum.

Submitted on May 3, 1962






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.