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Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 2, 156-161, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

DETECTION AND DISTRIBUTION OF CHLOROQUINE METABOLITES IN HUMAN TISSUES

Keiji Kuroda 1

1 Department of Chemistry, Medicat General Laboratory (406), United States Army Medical Command, Japan, APO 343, San Francisco, California

Metabolic products of chloroquine in human tissues and urine were studied by paper chromatography with the aid of ultraviolet spectroscopy, and the distribution of the products in tissues was examined based on chromatograms obtained. The results suggest that the drug undergoes slow metabolic conversions in man along a major pathway involving oxidations on the side chain which leads to the formation of 4-amino-7-chloro-quinoline.

Submitted on February 6, 1962






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.