JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldberg, L. I.
Right arrow Articles by Sjoerdsma, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldberg, L. I.
Right arrow Articles by Sjoerdsma, A.
Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 1, 39-46, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

ATTENUATION /OF CARDIOVASCULAR RESPONSES TO EXERCISE AS A POSSIBLE BASIS FOR EFFECTIVENESS OF MONOAMINE OXIDASE INHIBITORS IN ANGINA PECTORIS

Leon I. Goldberg 1, David Horwitz 1, and Albert Sjoerdsma 1

1 Experimental Therapeutics Branch, National Heart Institute, Bethesda, Maryland

The effects of exercise on heart rate and blood pressure of three patients with angina pectoris were determined before, during, and after treatment with a potent monoamine oxidase inhibitor, isocarboxazid. The elevated levels of heart rate and blood pressure produced by exercise were significantly reduced in each patient by isocarboxazid therapy. It is postulated that such attenuation of the cardiovascular response to exercise could be responsible for the effectiveness of monoamine oxidase inhibitors in the treatment of angina pectoris in some patients.

Submitted on February 21, 1962






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.