JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Heim, H. C.
Right arrow Articles by Erwin, V. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heim, H. C.
Right arrow Articles by Erwin, V. G.
Journal of Pharmacology And Experimental Therapeutics, Vol. 137, Issue 1, 107-113, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF EMETINE ON THE OXIDATION OF SUCCINATE BY HEART HOMOGENATES

Harold C. Heim 1, Harry C. Froede 1, and Virgel G. Erwin 1

1 Division of Pharmacology, School of Pharmacy, University of Colorado, Boulder, Colorado

Emetine produces a marked increase in the rate of oxidation of succinate by myocardial homogenates and mitochondria. This effect is observed with fresh, but not with aged, homogenates and appears to be related to a suppression of oxaloacetate accumulation, possibly through inhibition of malic dehydrogenase. The results bear considerable similarity to those obtained by other investigators who studied the effect of thyroxine on succinate oxidation.

Submitted on February 16, 1962






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.