TOXICOLOGY OF ACETOXYCYCLOHEXIMIDE AS A FUNCTION OF SEX AND BODY WEIGHT

¹ Bionetics Research Laboratories, Inc., Falls Church, Va.
² Hazleton Laboratories, Falls Church, Virginia, and Pharmacology and Experimental Therapeutics Service, General Medicine Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare
³ A. H. Robins Company, Inc., Richmond, Va.

Acetoxycycloheximide, an antibiotic with antitumor activity, was much more toxic to female rats than to males. It was also more toxic to female mice than to males, but no such difference occurred in dogs. Further, the toxicity of this compound for rats of differing age and weight was rendered nearly uniform by expressing dosage on a mg/animal basis. A mg/kg basis introduced, rather than removed, the factor of body weight. It is of interest that two closely related cycloheximide derivatives showed neither a sex-related difference nor a lack of dependence upon body weight. Also, a summary of the general toxicology of this compound was presented.