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Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 3, 397-399, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

ADJUNCTIVE VALUE OF ORAL PROPHYLAXIS WITH THE OXIMES 2-PAM LACTATE AND 2-PAM METHANESULFONATE TO THERAPEUTIC ADMINISTRATION OF ATROPINE IN DOGS POISONED BY INHALED SARIN VAPOR

James W. Crook 1, Alvin I. Goodman 1, Joseph L. Colbourn 1, Peter Zvirblis 1, Fred W. Oberst 1, and J. Henry Wills 1

1 U. S. Army Chemical Research and Development Laboratories, Army Chemical Center, Maryland

The effectiveness of two oximes, 2-PAM lactate and 2-PAM methanesulfonate, administered orally prior to exposure to lethal concentrations of Sarin vapor followed by atropine treatment was studied in dogs. Both oximes were effective in protecting animals exposed to Sarin and subsequently treated with atropine.

Blood oxime level at the start of exposure appears to be a determinant of eventual death or survival after exposure and subsequent treatment with a standard dose of atropine. Cholinesterase activity in red blood cells or in plasma after the exposure seems not to be related to the rate of recovery of the dog from prostration after exposure to Sarin. A blood level of oxime of 3 µg/ml is suggested for estimating in man the optimal dose and dosing schedule for oral employment of quaternary 2-formylpyridine oximes to attenuate the toxic effects of inhaled organophosphorus anticholinesterases.

Submitted on December 26, 1961




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Unequal Efficacy of Pyridinium Oximes in Acute Organophosphate Poisoning
Clin. Med. Res., March 1, 2007; 5(1): 71 - 82.
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