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Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 3, 318-326, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

THE CARDIOVASCULAR ACTIONS OF 7-(N-beta-METHYLPHENETHYLAMINOETHYL)THEOPHYLLINE HYDROCHLORIDE

J. Yelnosky 1, G. V. Kirkpatrick 1, and W. M. Govier 2

1 Department of Pharmacology, Research Division, McNeil Laboratories, Inc., Fort Washington, Pennsylvania
2 Warner-Lambert Research Institute, Morris Plains, New Jersey

R-720-11 causes a transient fall in blood pressure due to a peripheral vasodilator action and causes an increase in the heart rate and myocardial force of contractions which is likely due to an indirect sympathomimetic effect mediated by the release of one or more sympathomimetic substances, probably norepinephrine and epinephrine.

R-720-11 causes a marked increase in the blood pressure in a dog pretreated acutely with reserpine and conversely reserpine causes a marked pressor effect in a dog pretreated with R-720-11. It is believed that this occurs because under the combined influence of reserpine and R-720-11, the release of catecholamines from tissue stores is enhanced.

Submitted on January 22, 1962






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.