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Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 3, 293-297, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

ANTAGONISM OF LYSERGIC ACID DIETHYLAMIDE (LSD)-INDUCED HYPERTHERMIA

John T. Elder 1 and M. Kent Shellenberger 1

1 Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington

The pyretogenic response to LSD was prevented by 60-minute pretreatment with PBA. Reserpine given 24 hours before LSD and guanethidine 18.5 hours prior to LSD produced the most effective attenuation of the response. Reserpine given immediately before LSD caused an increased response to LSD, probably by increasing the metabolic rate. Hexamethonium had no effect upon the LSD response.

Submitted on February 16, 1962




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A. Horita and A. E. Hamilton
Lysergic Acid Diethylamide: Dissociation of Its Behavioral and Hyperthermic Actions by DL-agr-Methyl-p-Tyrosine
Science, April 4, 1969; 164(3875): 78 - 79.
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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.