![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
1 Wyeth Laboratories, Basic Medical Sciences Research Division, Philadelphia, Pennsylvania
A punishment discrimination was conditioned in laboratory rats by simultaneously rewarding with food and punishing with shock all lever responses made in the presence of a discriminative stimulus (tone). Appropriate setting of the shock intensity resulted in low and stable output of responses during the tone periods. A series of central nervous system depressants was administered in order to determine degrees of attenuation of the punishment discrimination relative to the side effects of nonspecific depression. Meprobamate, a di-urethan, produced the maximum attenuation at a dose that produced a minimum of side effects. The mono-urethans hedonal, emylcamate, and urethan produced the least attenuation. Pentobarbital and phenobarbital produced intermediate attenuating effects upon the punishment discrimination.
Submitted on December 23, 1961
This article has been cited by other articles:
|
|
 |
|
  S. C. Licata, D. M. Platt, J. M. Cook, P. V. V. S. Sarma, G. Griebel, and J. K. Rowlett Contribution of GABAA Receptor Subtypes to the Anxiolytic-Like, Motor, and Discriminative Stimulus Effects of Benzodiazepines: Studies with the Functionally Selective Ligand SL651498 [6-Fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one] J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1118 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Schoenfeld Lysergic acid diethylamide- and mescaline-induced attenuation of the effect of punishment in the rat Science, May 21, 1976; 192(4241): 801 - 803. [Abstract] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
