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Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 2, 250-258, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGY OF MITOMYCIN C: III. IN VITRO METABOLISM BY RAT LIVER

Herbert S. Schwartz 1

1 Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, N. Y.

The anaerobic metabolism of mitomycin C by rat liver homogenates and cell fractions was described. A TPNH-dependent system was localized in the microsomal (37000 x g) fraction. A more complex system, requiring DPN+, malate, ATP, and Mg++, was fully active only when mitochondria, microsomes and supernatant were recombined. When homogenates were supplemented with a TPNH-generating system no requirement for ATP, Mg++ or nicotinamide was evident although ATP had a sparing action with low concentrations of TPN+. Chemical reduction decreased toxicity in mice and antibiotic activity against B. subtilis.

Submitted on December 15, 1961




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.