JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mulé, S. J.
Right arrow Articles by Mellett, L. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mulé, S. J.
Right arrow Articles by Mellett, L. B.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*MORPHINE
*NALORPHINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 2, 242-249, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

DISTRIBUTION OF N-C14-METHYL LABELED MORPHINE: II. EFFECT OF NALORPHINE IN THE CENTRAL NERVOUS SYSTEM OF NONTOLERANT DOGS AND OBSERVATIONS ON METABOLISM

S. J. Mulé 1, L. A. Woods 2, and L. B. Mellett 3

1 Department of Pharmacology and Toxicology, University of Wisconsin, Madison, Wisconsin.
2 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City, Iowa
3 Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

The subcutaneous administration of labeled morphine prior to nonlabeled nalorphine resulted in a significant increase in the CNS levels of morphine in nontolerant dogs. Simultaneous injection of both drugs, or pretreatment with nalorphine resulted in an increase or no change in the CNS levels of morphine in nontolerant dogs as compared with the morphine control dog values.

The effect of nalorphine on the plasma and cerebrospinal fluid concentrations of free morphine was somewhat variable.

Paper chromatographic studies provided no evidence for the presence of an N-C14-methyl labeled metabolite of morphine in the CNS and urinary extracts of nontolerant and tolerant dogs.

Submitted on December 11, 1961




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. D. Napier, A. Stanfill, D. A. Yoshishige, K. E. Jackson, B. A. Barron, and J. L. Caffrey
Autonomic control of heart rate in dogs treated chronically with morphine
Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H2199 - H2210.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.