CANINE BLOOD SUGAR AND LACTIC ACID RESPONSES TO ADRENERGIC AMINES AFTER ADRENERGIC BLOCK

¹ Department of Pharmacology, School of Pharmacy, Oregon State University, Corvallis, Oregon

Two-hour infusions of the four amines, epinephrine, ethylnorepinephrine, Win-3046 or isoproterenol into dogs produced marked rises in blood sugar and lactic acid. If an infusion was preceded by the blocking agent phenoxybenzamine, this increase in blood sugar and lactic acid was strongly potentiated in every case. If the infusion was preceded by DCI, the production of blood sugar and lactic acid was strongly inhibited. When the same effects were measured after ergotamine, a rather indifferent block of blood sugar and lactic acid was obtained. An apparent inhibition by ergotamine occurred in each case but not all the differences were significant.

It is concluded that DCI is producing its effect here through its beta blocking ability or by blocking a special receptor for hyperglycemia; that phenoxybenzamine is not a blocking agent for blood sugar and lactic acid effects as produced in this experiment and that ergotamine is either a relatively weak blocking agent or one of mixed effect.