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Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 2, 179-182, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

BRAIN 5-HYDROXYTRYPTAMINE AND ANTICONVULSANT ACTIVITY

E. G. Anderson 1, S. D. Markowitz 1, and D. D. Bonnycastle 1

1 Department of Pharmacology, Seton Hall College of Medicine and Dentistry, Jersey City, New Jersey

The relationship between the rise in brain 5-hydroxytryptamine and anticonvulsant action of diphenylhydantoin has been investigated, and some correlation between the time courses of each was noted. However, comparison of the relative effects of diphenylhydantoin, phenylisopropyl hydrazine and 5-hydroxytryptophan on the maximal extensor reflex in response to electroshock and rise in brain 5-hydroxytryptamine showed a complete lack of correlation.

Submitted on December 23, 1961






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