JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Elder, J. T.
Right arrow Articles by Dille, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Elder, J. T., Jr.
Right arrow Articles by Dille, J. M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 2, 162-168, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

AN EXPERIMENTAL STUDY OF THE PARTICIPATION OF THE SYMPATHETIC NERVOUS SYSTEM IN THE LYSERGIC ACID DIETHYLAMIDE (LSD) REACTION IN CATS

John T. Elder Jr. 1 and James M. Dille 1

1 Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington

Of the drugs scopolamine, atropine, hexamethonium, reserpine, hydralazine, phenoxybenzamine and chlorpromazine, only phenoxybenzamine and chlorpromazine were effective as antagonists of the behavioral effects induced by LSD.

Surgical sympathectomy and adrenal demedullation did not affect the behavior pattern induced by LSD.

Reserpine did not prevent the behavioral changes induced by LSD, but caused the animals so treated to develop a catatonic-like state immediately the typical behavior pattern ceased.

It is concluded that chlorpromazine and phenoxybenzamine are effective through depression of central sympathetic control areas.

Submitted on December 21, 1961






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.