JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buñag, R. D.
Right arrow Articles by Walaszek, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buñag, R. D.
Right arrow Articles by Walaszek, E. J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 136, Issue 1, 59-67, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

DIFFERENTIAL ANTAGONISM BY BAS-PHENOL OF RESPONSES TO THE INDOLEALKYLAMINES

Ruben D. Buñag 1 and Edward J. Walaszek 2

1 Department of Pharmacology, UE-RM Memorial Medical Center, Quezon City, Philippines
2 Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas

Studies were made on the antagonistic effect of BAS-phenol on blood pressure responses of different animal species to various indolealkylamines. In the dog, BAS-phenol selectively blocks responses to serotonin, bufotenine, 4-hydroxytryptamine, psilocin and psilocybin but not those to tryptamine or dimethyltryptamine. A similar differentiation could usually be shown in the cat and the rabbit but not in the chicken. Differentiation between serotonin and tryptamine by selective specificity of BAS-phenol antagonism could not be demonstrated in the isolated guinea-pig ileum and rabbit ear preparations.

Submitted on October 2, 1961






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.