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Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 2, 230-232, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF PENTOBARBITAL AND ETHER NARCOSIS ON THE BRAIN CONCENTRATION OF VARIOUS ESTERS WITH ACETYLCHOLINE ACTIVITY

E. A. Hosein 1 and Roushan Ara 1

1 Department of Biochemistry, McGill University, Montreal, Canada

Paper chromatographic analysis of extracts of rat brain, followed by biological assay with the frog rectus preparation of the eluates of specific bands from the chromatograms, showed that the administration of either pentobarbital or ether to produce deep anesthesia in these animals, caused a significant increase of the acetylcholine activity in the brain. This increased acetylcholine activity was, perhaps, mainly due to the increased concentration of either one or several of the CoA ester derivatives of gamma-butyrobetaine, crotonbetaine and carnitine.

Submitted on July 3, 1961






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