JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buñag, R. D.
Right arrow Articles by Walaszek, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buñag, R. D.
Right arrow Articles by Walaszek, E. J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 2, 151-155, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

THE MECHANISM OF SEROTONIN AND TRYPTAMINE INDUCED VASODEPRESSION IN THE CHICKEN

Ruben D. Buñag 1 and Edward J. Walaszek 2

1 Department of Pharmacology, UE-RM Memorial Medical Center, Quezon City, Philippines
2 Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas

Chickens were depleted of tissue histamine by repeated injections of compound 48/80. Such animals were found to respond to injections of tryptamine or serotonin with a rise in arterial pressure instead of the usual fall. Bioassays for histamine done on urine samples taken after injections of serotonin, tryptamine or compound 48/80 showed significant increments in histamine content. The implication of these findings in relation to the involvement of a histamine mediated mechanism in the depressor response of the chicken to serotonin and tryptamine is discussed.

Submitted on July 5, 1961






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.