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Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 1, 89-93, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON CELLULAR ADAPTATION TO MORPHINE AND ITS REVERSAL BY NALORPHINE IN CEREBRAL CORTICAL SLICES OF RATS

A. E. Takemori 1

1 Department of Pharmacology, State University of New York, Upstate Medical Center, Syracuse, New York

Cellular adaptation to morphine using cerebral cortical slices of rats can he acquired within a week of morphinization to the rats and can be lost within a week after abrupt withdrawal from the narcotic.

The in vivo injection of nalorphine promptly reverses the adapted state of the rats' cortical slices so that the slices again become sensitive to the depressive effect of morphine.

Nalorphine can antagonize the depressive effect of morphine in vitro, but the antagonism depends on the molar ratio of antagonist:agonist employed. The most effective reversal is seen when the molar ratio is either 1:4 or 1:10.

Submitted on June 16, 1961






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.