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Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 1, 71-78, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE INOTROPIC ACTION OF ALDOSTERONE ON ISOLATED CARDIAC TISSUE PREPARATIONS; INCLUDING THE EFFECTS OF pH, OUABAIN AND SC-8109

Ralph D. Tanz 1

1 Department of Physiology, School of Medicine, Western Reserve University, Cleveland, Ohio

The inotropic action of aldosterone on various in vitro cardiac preparations was investigated. The results obtained are presented as evidence that the addition of dl-aldosterone ( 1 x 10-5 µg/ml) to the perfusate has the ability to produce a positive inotropic action on the cat papillary and whole isolated heart preparations. Furthermore, the observed positive inotropic action is the result of a direct effect upon the myocardium.

Ancillary studies showed that a reduction in the NaHCO3 concentration lowers the pH of the perfusate and apparently increases the sensitivity of cardiac tissue to aldosterone, as well as providing a more stable preparation. In addition, the renal-aldosterone antagonist, SC-8109, is also able to produce a positive inotropic action but our data suggest that it does not antagonize the cardiotonic action of aldosterone, nor the cardiotoxic action of ouabain.

Submitted on June 19, 1961




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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.