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Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 1, 7-10, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

A SENSITIVE ASSAY OF MONOAMINE OXIDASE ACTIVITY IN VITRO: APPLICATION TO HEART AND SYMPATHETIC GANGLIA

Walter Lovenberg 1, Robert J. Levine 1, and Albert Sjoerdsma 1

1 Experimental Therapeutics Branch, National Heart Institute, Bethesda, Maryland

A sensitive method of measuring monoamine oxidase in vitro based on the rate of indoleacetic acid formation from tryptamine is described. The method is particularly suited for studies on organs with low levels of enzyme activity, e.g., dog heart, or on small samples of tissue, such as a sympathetic ganglion. Correlation of the biochemical and pharmacologic effects of MAO inhibitors in such loci will thereby be facilitated.

Submitted on June 17, 1961






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.